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KMID : 0881720110260040377
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Journal of Food Hygiene and Safety
2011 Volume.26 No. 4 p.377 ~ p.382
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Acute Oral Toxicity and Skin Irritation Studies on Lamia-Kill Composed of Benzalkonium Chloride and Citric Acid
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Cha Chun-Nam
Lee Yeo-Eun
Son Song-Ee
Yoo Chang-Yeul
Park Eun-Kee
Choi Hyun-Ju
Kim Suk
Lee Hu-Jang
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Abstract
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This test was performed to evaluate the acute oral toxicity and skin irritation of Lamia-Kill®, disinfectant, containing 20% benzalkonium chloride and 10% citric acid. In acute oral toxicity, Lamia-Kill® was orally administered at dose levels of 2,000, 1,000, 500, 250 and 0 mg/kg body weight. After single oral administration to both sexes of SD rats, the rats were observed for 14 days. In primary skin irritation test, New Zealand white rabbits were dermally treated with Lamia-Kill® for 24 hr and observed for 3 days. All rats treated with Lamia-Kill® were induced no toxic signs in mortalities, clinical findings, body weights and gross findings. Also, the disinfectant did not induce any adverse reactions such as erythema and edema on intact skin sites for the most part rabbits, but on abraded skin sites, some rabbits showed very slight erythema on 24 hr after topical application. With the results of this study, Lamia-Kill® have no effect on acute toxicity and side effect in SD rats and was classified as a practically non-irritating material based on the score 0.50 of primary irritation index.
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KEYWORD
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Disinfectants, Benzalkonium chloride, Citric acid, Acute oral toxicity, Skin irritation
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